Prognostic significance of the breast milk microRNA impact on the immune response of a newborn with intrauterine growth retardation

This literature review provides current information about intrauterine growth retardation (IGR) as one of the causes perinatal morbidity and mortality. There is a sustaining trend to augmentation UGR level despite new methods diagnostics, treatment prevention development. Furthermore, there high percentage complications among children with IGR at any age. Therefore, early diagnostics accompanying diseases in sparks interest, especially view fact diagnostic incipience. The article highlights features neonatal immune response, including IGR. These data indicate predominance non-specific response over specific one, prevalence generalized inflammation, decreased activity phagocytes, neutrophils, antigen-presenting cells (APC) most Toll-like receptor agonists (TLRAs), levels interleukin-6 interleuken-23. Moreover, analyzed sources demonstrate spurt proinflammatory factors, their relatively low neonates right after birth. Increased cytokines on ground systemic inflammation an unfavorable factor course disease. In addition, contents microRNA presence breast milk. MicroRNAs are small non-coding RNAs 19–23 nucleotides length that regulate expression target gene. Breast milk microRNAs resistant enzymes gastrointestinal tract child mainly absorbed. data, proving change transcriptome depending gestational age, nature labor, mother's diet, her medication. According mentioned studies, microRNA, detected stages lactation (miR-155, miR-148a, miR-146b, miR-181a, miR-181b, miR-17), probably pro- anti-inflammatory acuity child's response. Research may be important for prediction possible inflammatory We used such databases Scopus, Web Science, MedLine, PubMed, Google Scholar, CyberLeninka, RSCI writing article. No conflict interest was declared by author. Key words: retardation, restriction, IGR, milk, miR, immunity, review.